A division with

Marquette, Memphis, Depaul, Cincy, Louisville, Houston, SMU, UCF

another with

UCONN, Georgetown, Providence, Rutgers, St. Johns, Seton Hall, Villanova, USF

Have Notre Dame, play home games against one division, and road games against the other division every year.

Keeps everything as regional as possible. Keeps travel costs down. Keeps student athletes as close to their home campus as possible.
You could have each team in each division play each other Home/Away, and play Notre Dame and another team in another division every year.

Thoughts, opinions, etc?