TCU will play its first season of football as a member of the Big East in 2012. There have been some questions about just what TCU's schedule can expect to be with the conference still considering expansion to ten or possibly twelve football members. Even with that question still unanswered, the Horned Frogs' Big East schedule for the 2012 season should be easy to derive from the way the current unbalanced conference schedule plays out now.
- Four road games: Cincinnati, Louisville, South Florida, West Virginia
- Three road games: UConn, Pitt, Rutgers, Syracuse
- Home - Cincinnati, Louisville, South Florida, West Virginia
- Away - UConn, Pitt, Rutgers, Syracuse